Here are a couple of videos from Gun Sam on the .22 Long Rifle as a possible defensive round. The big problem you will always hear about with .22 Long Rifle is reliability. Premium cartridges tend to run nearly at 100 percent, but not quite as good as centerfire ammunition. The little micro pistols will malfunction more than larger pistols. They require more fastidious cleaning and lube, plus a firm grip to add mass to the pistol frame in order to function reliably. Elderly arthritic hands are not a good platform to run micro semi-auto .22s. Gun Sam chose round nose Mini Mags as his choice because of penetration. Hollow points and flat point designs will make a bigger wound channel. Listen to Tim Sundles on stopping dangerous game, and then draw your own conclusions. .22 Long Rifle probably will not penetrate out the other side of a rib cage, so over-penetration is less of a concern than with centerfire ammo. The heart is right behind the ribs, so I tend to think the wound channel is a higher priority than penetration with rimfire ammo. Avoiding a gunfight is preferable to having to fight...
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